The next step for AstraZeneca is to have its vaccine approved by regulators. The vaccine still needs to be approved by regulatory authorities So far, no serious safety concerns have emerged from the clinical trials, which were conducted with over 23,000 people. That said, these interim results are in line with a peer-reviewed study published in medical journal Lancet last week, which found that the AstraZeneca vaccine bolstered the immune response to Covid-19 in older adults, who are most at risk of developing severe versions of the disease. More study will be needed to answer this question. The third possibility is that the larger initial dose may be causing the body to develop antibodies against the vaccine itself, blunting the impact of the booster shot. The second possibility is that the smaller initial dose may stimulate “memory cells” in the immune system, priming the body to produce antibodies in greater quantities when the second dose is administered. First is that the difference may just be a statistical artifact - a consequence of the fact that this is an interim data analysis, and that once the final results are in the difference may be smaller. It’s not entirely clear why the smaller initial dose produces better results, though scientists in the field have suggested several ideas. Paradoxically, the second group, which had the larger initial dose, showed that the vaccine was only about 62% effective. In the first group, the interim data analysis found that the vaccine was about 90% effective at preventing Covid-19. In the second group, patients were given the same dose both initially and as a booster one month later. ![]() In one group, patients were given a smaller initial dose of the vaccine (or placebo), then a larger dose as a booster one month later. ![]() The preliminary data released on Monday studied two different ways to administer the vaccine. Preliminary results suggest that this adenovirus vaccine can be effective
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